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Malarial anemia is associated with a shift in iron distribution from functional to storage compartments. This suggests a relative deficit in erythropoietin production or action similar to that observed in other infections. Our study in Kenyan children with asymptomatic malaria aimed at investigating whether malaria causes increased erythropoiesis, and whether the erythropoietic response appeared appropriate for the degree of resulting anemia. Longitudinal and baseline data were used from a trial with a 2 ؋ 2 factorial design, in which 328 anemic Kenyan children were randomly assigned to receive either iron or placebo, and sulfadoxinepyrimethamine or placebo. Erythropoiesis was evaluated by serum concentrations of erythropoietin and soluble transferrin receptor. Prospectively collected data showed that malarial infection resulted in decreased hemoglobin concentrations, and increased serum concentrations of erythropoietin and transferrin receptor. Conversely, disappearance of malarial antigenemia resulted in increased hemoglobin concentrations, and decreased concentrations of these serum indicators. Additionally, our baseline data showed that current or recent malarial infection is associated with increased serum concentrations of erythropoietin and transferrin receptor, and that these were as high as or perhaps even higher than values of children without malarial infection and without inflammation. Our findings indicate that in asymptomatic malaria, the erythropoietic response is adequate for the degree of anemia, and that inflammation probably plays no or only a minor role in the pathogenesis of the resulting anemia. Further research is needed to demonstrate the role of deficient erythropoietin production or action in the pathogenesis of the anemia of symptomatic malaria. (Blood. 2002;100: 3489-3494)

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Reaction between NaMo(CO)3C5H5 and benzyl chloride gives the yellow -benzyl derivative C6H5CH2-Mo(CO)3C5H5. Irradiation of this compound in hexane solution gives a low yield of the red -benzyl derivative C6H5CH2Mo(CO)2C5H5. The temperature dependence of the proton nmr spectrum of this -benzyl derivative is discussed. The proton nmr spectrum of the -cycloheptatrienyl derivative C7H7Mo(CO)2C5H52 was also found to be temperature dependent. Numerous-allyl derivatives of transition metals such as [C3HsPdCl]2,3 C3H6Co(CO)3,4'5 C3H5-Mn(CO)4,5•6 C3H5Fe(CO)3I,7-9 and C3H5Mo(CO)2-C5H510 have been described. We wish now to report the first definite example11 of a -benzyl derivative in which three carbon atoms of the -benzyl ligand, two of which are located in the benzene ring, are apparently complexed with the metal atom.The -benzyl ligand is a benzolog of the -allyl ligand, a relationship entirely analogous to that of the -indenyl ligand and the -cyclopentadienyl ligand and to that of naphthalene and benzene.