Background: One of the most important causes that can increase the risk of hospitalization and death in chronic obstructive pulmonary disease is comorbidity. The aim of this study was to identify the proportion of comorbidity among hospitalized patients with chronic obstructive pulmonary disease in a teaching hospital, West Java, Indonesia, from January to December 2012. Methods: A descriptive study was conducted from September to November 2013 in Internal Medicine Department of Dr. Hasan Sadikin General Hospital Bandung. The study used 107 medical records that consisted of data about patients with chronic obstructive pulmonary disease (COPD) who were hospitalized between January to December 2012. The medical records were collected using simple random sampling. Variables identified in this study were characteristics of the patients (age, sex, and smoking history) and comorbidity events. Comorbidity events were coronary artery disease (CAD), lung cancer, diabetes mellitus (DM) type 2, anemia, dyslipidemia, osteoporosis, depression, pulmonary artery hypertension (PAH), and hypertension. Age variable was divided into 3 categories with interval 20 years. All collected data were presented in frequency distribution. Results: Most of the patients in this study were 50-69 years old, male, and had smoking history. The highest proportion of comorbid condition was hypertension, followed by anemia and coronary artery disease. Conclusions: Patients with COPD have one or more other diseases (comorbidity). Three most frequent comorbidities are hypertension, anemia, and coronary artery disease. [AMJ.2015;2(4):

Salah satu upaya mengurangi peningkatan penduduk, yaitu dengan menggunakan kontrasepsi. Namun penggunaan kontrasepsi pria masih minim sehingga diperlukan upaya untuk meningkatkan penggunaan kontrasepsi pria. Buah pare merupakan tanaman tradisional yang dapat digunakan sebagai bahan kontrasepsi karena mengandung kukurbitasin. Tujuan penelitian ini adalah mengetahui pengaruh buah pare terhadap ketebalan tubulus seminiferus pada mencit jantan sehingga memberikan efek infertil. Penelitian dilakukan di Laboratorium Biologi Medik Fakultas Kedokteran Universitas Padjadjaran pada 17 Mei sampai 20 Juni 2018. Pengukuran ketebalan tubulus seminiferus dimulai dari spermatogonia pada lapisan basal sampai dengan kepala spermatid pada distal lumen. Subjek penelitian yang digunakan adalah 28 ekor mencit jantan yang dibagi menjadi empat kelompok; kelompok kontrol negatif, perlakuan 1 (P1) yang diberi dosis 280 mg/kgBB/hari, perlakuan 2 (P2) yang diberi dosis 560 mg/kgBB/hari dan perlakuan 3 (P3) yang diberikan dosis 1.120 mg/kgBB/hari. Ketebalan tubulus seminiferus normal pada mencit adalah 54-62 mm. Dari hasil uji hipotesis one way ANOVA, pemberian ekstrak etanol pare menurunkan ketebalan tubulus seminiferus secara keseluruhan, dengan ketebalan mencapai 39,56 mm pada dosis optimal 1.120 mg/kgBB/hari. Zat aktif kukurbitasin mempunyai struktur mirip dengan steroid sehingga dapat menurunkan kadar testosteron dan memengaruhi spermatogenesis. Sel spermatogenik yang menurun menyebabkan penurunan ketebalan tubulus seminferus.