Cigarette smoking is the single most preventable cause of several diseases and premature deaths. Cigarette smokers have a higher risk of coronary artery disease than non-smokers. Several possible explanations have been offered for this association of which one is through its dyslipidemic effects. AIMS: 1. To evaluate the variation in lipid profile with respect to number (in packs) of cigarettes smoked per day. 2. To evaluate the variation in lipid profile with respect to duration (in years) of cigarette smoking. SETTINGS AND DESIGN: Out of 240 subjects 120 were nonsmokers and 120 were smokers. All the subjects were healthy and free from any major illness METHODS AND MATERIAL: Subjects were asked to refrain from non-vegetarian diet for three days. Blood sample was collected after overnight fasting and analysed for lipid profile. STATISTICAL ANALYSIS: ANOVA test was used for analysis. RESULTS AND CONCLUSION: The present study shows increase in total cholesterol, triglycerides, low density lipoproteins, ratio of TC/HDL-C and LDL-C/HDL-C and decrease in high density lipoproteins, with increase in number of cigarettes (In packs) and increase in number of years of smoking. In the view of double risk for smokers (Smoking and altered lipid Profile) efforts may be made to introduce smoking cessation clinics and awareness programmes regarding ill-effects of smoking from school level itself.