antihypertensives class, 184 for M04-gout preparations, 135 for C10-lipid modifying agents and 218 for B03-antianaemic preparations. 64% of patients (139) used gastroprotectors, especially proton pump inhibitors (PPIs). 3 DDIs, of 289 detected, were considered contraindicated and potentially serious, and were due to antipsychotic drugs. Drugs most responsible for DDIs were: cardioaspirin, PPIs, angiotensin receptor blockers and diuretics. 975 (4.2±2.2 per patient) and 571 (2.4±1.7 per patient) inappropriate drugs were identified according to STOPP criteria and Beers criteria, respectively. Conclusion and relevance Polypharmacy is associated with a high incidence of DDIs and an increased risk of mortality and hospitalisation. The use of the ICT tool and the clinical pharmacist who bring their contribution in terms of pharmacological and pharmacokinetic knowledge have significantly contributed to the improvement in prescriptive appropriateness and minimised the risk of adverse events. REFERENCES AND/OR ACKNOWLEDGEMENTS 1. Critical analysis of the information and communication technologies' (ICT) tools most used in clinical practice by the pharmacist. Masucci S, Cerutti E, Riba M, Gasco AL (EAHP Congress 2019).

Background The World Health Organization declared COVID-19 a pandemic in March 2020. The first vaccine became available in December, with practically no post-marketing data. Methods An analytical cross-sectional survey-based study was conducted in a third-level hospital in Spain between March and April 2021 to describe the difference in adverse events with the BNT162b2 and mRNA-1273 COVID-19 vaccines. The participants were hospital workers who completed a survey voluntarily at least 14 days after the last vaccine. The STROBE checklist was followed. Results One thousand two hundred and forty-nine respondents completed the survey; 48% (599) received mRNA-1273 and 52% (650) BNT162b2. Fourteen thousand four hundred and two adverse reactions were recorded, 6896 local (3939 with mRNA-1273 and 2957 with BNT162b2 (6.6 vs 4.4 reactions per patient)) and 7506 systemic (4460 with mRNA-1273 and 3046 with BNT162b2 (7.4 vs 4.7 per patient)). Local reactions were more frequent after the first dose, while systemic reactions were higher after the second, for both vaccines and in a higher percentage with mRNA-1273 compared to BNT162b2 (p-value<0.05). Conclusions Licensed mRNA vaccines were highly safe when administered under post-marketing conditions among working-age adults. The main adverse events were mild, although they occurred in most patients, especially after the mRNA-1273 vaccine.

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ALT), gamma glutamyl transferase (GGT), alkaline phosphatase (ALP) and total bilirubin (TB)), dose, diagnosis, age and sex were registered.Microsoft Excel was used for the statistics calculation. Results 68 determinations in 38 patients (73.75% men; aged 64.84 ±11.29 years).Diagnosis: probable disease 21 (55.28%), possibility 12 (31.57%), prophylaxis 5 (13.15%).6 (15.8%) patients needed a change in treatment. 5 (83.33%) had the dose changed in order to maintain plasma levels between 1 and 5.5 mg/mL. In 1 patient (16.66%) voriconazole was substituted.28 (73.7%) started treatment with the dose of 200 mg/12 hours, whereas the rest (26.3%) has a higher dose. 60% of dose changes were in patients taking 200 mg/12 hours.A positive correlation existed between plasma levels of voriconazole and liver enzymes as well as with cholestasis markers (AST: r 2 =0.1817; ALT: r 2 =0.1118; GGT: r 2 =0.2528; PA: r 2 =0.2444 and TB: r 2 =0.4637).The Chi-square statistic was significant at p<0.05 for plasmatic levels over 3 mg/mL and AST/ALT over physiological range (35 U/L).The relative risk of presenting ALT over the physiological range is 3.12 and for AST 2.31 in patients with plasmatic levels of voriconazole >3 mg/mL respects the ones whose plasmatic levels were <3 mg/mL. Conclusion and relevanceVoriconazole TDM is a tool that can help to avoid treatment failure and adverse events. Its relationship with liver toxicity, which shows our data, TDM would help to prevent these side effects.

According to the ATE Guide, it would fit with a type A therapeutic positioning, assuming that the OS variable studied for pembrolizumab does not meet statistical significance for patients with squamous histology. Conclusion and relevance Nivolumab, pembrolizumab and camrelizumab could be considered ATE. It is necessary to take into account that there is a certain degree of uncertainty in this positioning result.