MEASUREMENT OF GASTRO-INTESTINAL BLEEDING BEMIX At times a lack of correspondence has been observed between the two methods. On the one hand, significant radioactivity has been found with negative benzidine tests (as in days 3 and 4 of Case 2); and on the other, weakly positive benzidine reactions have been observed with no significant radioactivity in the faecal samples. These discrepancies have always been when the amount of blood was small as indicated by one test or the other. Discussion Quantitative chemical methods for determining the amount of blood present in faeces are laborious and inexact (Andrews and Oliver-GonzAlez, 1942). For this reason very little information is as yet available about the daily blood loss in many common diseases. The radio-isotope method is simpler, and its general validity was carefully worked out in experiments with dogs by Owen et al. (1954a). They labelled dogs' own red cells with

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