Phys. 36, 977 (1964). 18 Use is made of the following relation between decay width T and transition amplitude A: T = lA^m^/m^*,In a recent work Bryan and Scott 1 cast the nucleon-nucleon potentials in the form V= V {0) + T 1 -r 2 V il \ where both V i0) and V il) have the formswhere the V {0) terms arise from the exchange of isoscalar mesons and V a) arise from isovector mesons. They present a set of eight one-boson-exchange potentials derived from pseudoscalar, vector, and scalar meson theory. These are compared with corresponding potentials extracted from a phenomenological model due to Lassila, Hull, Ruppel, McDonald, and Breit 2 and a phenomenological model due to Hamada and Johnston. 3 The results show good agreement, particularly in view of the fact that they use only nine adjustable parameters. Purely phenomenological studies of the nucleon-nucleon interaction have gone higher than thirty adjustable parameters. The success of Bryan and Scott's work has led us to re-examine a closely related study which was reported 4 at the June, 1949 meeting of the American Physical Society in Cambridge.In this study of two Dirac particles coupled five-vector ially (scalar plus four-vector), one obtains the chief explicit interaction ^ = (l-^1/3 a -3 1 -S 2 )J.(2)In the usual form of meson theory, J is the Yukawa potential. Following Breit's 5 method, the small components of the Dirac wave function were eliminated to obtain the Schrodinger-Pauli interaction V = -(/z/Mc) 2 {v 2 J/4 + 2JV 2 + 2VJ-V -(V 2 J/6)oy a 2 -2r-1 (^e//^r)L-S + (&)[rd(r~ldJ/dr)/dr]S l2 }.The major burden of the earlier study was 380 where p stands for the final state momentum and m B * and mo for the masses of the initial baryon resonance and the final baryon, respectively.to show that a plausible interpretation could be given to some of the properties of the deuteron with this five-vector interaction. In this connection particular use was made of a twoparameter trial wave function,whereThis spherically symmetric wave function was assumed to represent approximately the ground state of the deuteron, and the expectation values of various terms in the Schrodinger interaction were assessed in terms of the coupling constant and the meson mass parameter. In addition the Diracian pseudoscalar-pseudoscalar interaction v = PAr5ir52 Jwas considered. This explicit interaction also arises out of a five-dimensionally invariant interaction between a spinorial and tensorial field as discussed by Watanabe. 6 If this is reduced to large components one findsThe recent discovery, mass measurement, and classification of heavy strongly interacting mesons along with the extensive phenomenological studies of the nucleon-nucleon interaction provide the opportunity to test the interactions described by Eqs. (2) or (3) and (5) or (6). For this initial study we choose as a universal coupling constant the pi-meson nucleon coupling constant, ^ = 14.7 as deduced by Hamilton and Woolcock 7 from pion-scattering experiments. Figures 1(a), 1(b), and 1(c) show the tensor, spin-spin,...

The androgen receptor (AR) is activated in patients with castration resistant prostate cancer (CRPC) despite low circulating levels of androgen, suggesting that intracellular signaling pathways and non-androgenic factors may contribute to AR activation. Many G-protein coupled receptors (GPCR) and their ligands are also activated in these cells indicating a role for these in CRPC. Although a cross talk has been suggested between the two pathways, yet, the identity of GPCRs which may play a role in androgen signaling, is not established yet. We demonstrate that adhesion GPCR 205, also known as GPR56, can be activated by androgens to stimulate the Rho signaling pathway, a pathway that plays an important role in prostate tumor cell metastasis.Testosterone stimulation of GPR56 also activates the cAMP/ Protein kinase A (PKA) pathway, that is necessary for AR signaling. Knocking down the expression of GPR56 using siRNA, disrupts nuclear translocation of AR and transcription of prototypic AR target genes such as PSA.GPR56 expression is higher in all prostate tumor samples tested and cells expressing GPR56 exhibit increased proliferation. These findings provide new insights about androgen signaling and identify GPR56 as a possible therapeutic target in advanced prostate cancer patients.

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