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Various factors associated with experimental parathyroidectomy (PTX) by cautery technique result in hypocitricemic responses. The conditions of surgical stress result in a decrease in plasma citrate and plasma calcium within two hours. Cautery of the thyroid gland which releases calcitonin produces a marked hypocitricemic response wiU .. in two hours which follows the hypocalcemia. Corroboration of this effect was obtained by the hypocitricemic effect of injected calcitonin. Within flVe ho urs PTX results in a decrease in plasma citrate which can be distinguished from the calcitonin effect. Calcitonin is able to decrease the plasma citrate level of animals made hypocitricemic by PTX. The studies reveal that various conditions can result in early hypocitricemic responses which can be mistaken for or can mask the effect of the hypoparathyroid state of the anima!. The results also demonstrate that calcitonin is antagonistic to parathyroid hormone in its effect on plasma citrate as weil as calcium. Horm. Metab. Res. 3: 120-125 (1971) K e y-W 0 r d s: Citrate-Calcitonin-Parathyroidectomy-Surgical Stress-Calcium ..

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