These findings suggest that abnormal satiety response is a strong contributor to the energy imbalance in 16p11.2 CNV carriers, and, akin to other genetic forms of obesity, altered satiety responsiveness in children precedes the increase in BMI observed later in adolescence.

No abstract

SummaryReaction of l,l-dichloro-2,5-diphenylbenzocyclopropene (10a) with 1 equiv. of silver fluoride yields 1-chloro-l-fluoro-2,5-diphenylbenzocyclopropene (1Oc). Both 10a and 1Oc react with excess silver fluoride to give the difluoro compound lob. Both 10b and 1Oc are also prepared via cyclo-additions of 1,2-dichloro-3,3-difluorocyclopropene ( we turned our attention first to the much more stable 2,5-diphenyl derivatives [8] for obtaining a 1 -halogeno-2,5-diphenylbenzocyclopropene (6) and ultimately 2,sdiphenylbenzocyclopropenium ion (7). Our first approach consisted in aromatization of 1,6,7-trichloro-2,5-diphenylbicyclo [4.1 .O]hept-3-ene (8) available by partial reduction of the Diels-Alder adduct 9 of diphenylbutadiene and tetra-

The title compound 1 is shown to give, both upon direct irradiation at 254 nm and upon acetophenone-sensitized photolysis at 300 nm, the syn -vinyl-pentamethylhousene 5, which spontaneously rearranges in a [3,3]-sigmatropic process to give the bicyclo[3.2.0]heptadiene skeleton 2. Based on the photochemical behaviour of selectively deuterated starting material, the suggestion is made that the direct photolysis produces the vinylhousene skeleton by a classic electrocyclization, whereas the sensitized reaction reaches the same target via a di-n-methane rearrangement. The bicyclo[3.2.0]heptadiene derivative 2 gives pentamethylhomoprismane 3 upon prolonged irradiation at 254 nm.