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6-Hydroxy derivatives of R-(-)-carvone and 7,8-epoxycarvone were synthesized and subjected to oxidative ring cleavage by the action of lead tetraacetate. These reactions followed different patterns, depending on the substrate structure.

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New procedure was developed for preparation of the fragment С 10 -С 21 of epothilone D analog from R-(-)-carvone. The key stage of the synthesis consists in the regio-and stereoselective Wittig reaction of (5R)-5-acetyl-2-methylcyclohex-2-en-1-one with an ylide generated from tributyl[(2-methylthiazol-4-yl)methyl]phosphonium chloride.Epothilones, especially their analogs, are very promising objects for designing and synthesis of anticancer compounds of tubulin-polymerizing (taxol-like) action [1][2][3]. In our planned synthetic approach to analogs of epothilone D 1a and 1b [4-6] a block 2 with thiazole substituent is one of the key synthons (Scheme 1).