Climate change is indicated by extreme weather changes, namely drought on agricultural land, thus limiting crop growth. The availability of rice as a food source in developing countries has not met the increasing food needs of the population. The low planting area and productivity, which are said to be the triggers for the problem, can be overcome by nutrient management on dry land. Iron serves a function in the physiology and metabolism of plants. Iron sprayed on the leaves in the form of nano Fe2O3 can increase the efficiency of nutrient absorption by plants. This study aims to evaluate the effect of the application of nano Fe concentration on rice growth in drought-stress conditions. The study was conducted in the Sleman experimental field using the Split Plot Design method with two factors (water content of 100; 50% and nano-Fe concentration of 0; 0.5; 1; 1.5; 2 ppm). Based on the results of the study showed that there was an independent effect of treatment on growth. Spraying nano Fe 0.5-1 and 1.5-2 ppm reduced membrane damage by 3.27% and 8.25% respectively, and there was a negative correlation between membrane damage and growth parameters.