We demonstrate a new and high-yielding
method for removal
of benzylidene
acetals and para-methoxybenzyl ethers under catalytic
conditions (BF3:OEt2 orFeCl3, 10
mol%) with mercaptoacetic acid as a scavenger. The reaction coproducts
are converted to water-soluble molecules, which can be removed by
aqueous extraction, thereby bypassing the need for chromatographic
purification. The reaction was demonstrated on both multimilligram
and multigram scale.
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