Guillain-Barré syndrome is a post infective polyradiculoneuropathy having heterogenous clinical presentation and various subtypes like acute inflammatory demyelinating polyradiculoneuropathy, acute motor-sensory axonal neuropathy, acute motor axonal neuropathy, pure sensory variant and Miller Fisher syndrome. A prospective study was carried out in patients with Guillain-Barré syndrome admitted to the RNT Medical College & attached Hospital to determine the electrophysiological subtypes and their prognosis in relation to various subtypes, clinical features and treatment. A total of 100 patients was enrolled. In the final analysis there were 74% male and the mean age was 30.4 years. Clinically 97% patients had quadriparesis, 2% had paraparesis and one cases had bibrachial involvement. Cranial nerves and respiratory involvement were seen in 25% and 24% cases respectively. Electrophysiologically the most common type of GBS was AIDP (43%) followed by AMAN (34%) and AMSAN (23%). The prognosis was assessed at one month and found that there was complete recovery in 32% cases and residual weakness in 63% cases. Death occurred in 5% cases because of respiratory involvement.

surgery, 72(69.9%) received PDS whilst 26(25.24%) had Interval debulking surgery(IDS). CCR was achieved in 10(9.5%) cases, whilst optimal and suboptimal cytoreduction was achieved in 95(90.5%) patients. OS in patients having surgery was 42.4 months, with a 1-year survival of 83.33% and 5year survival of 27%. 26(20.31%) patients received chemotherapy only as a treatment option with an OS was 25.2 months, with a 1-year survival of 61.53% and 5-year survival of 7.69%. From the 16 patients who received best supportive care, 14/16(87.5%) died within 6 months following diagnosis. Conclusion* The amount CCR achieved during debulking surgery was noted to be low. In order to achieve better results, it may be appropriate that AOC treatment strategy is revised, by either moving towards IDS, which we have seen in the latter 3 years, or by investing in improving the surgical expertise. Despite low levels of CCR, survival rates are comparable with other European centres.

Data for thrombocytopenia cases are very few so we can't make any opinion over this except that most of the cases of OC have normal or above normal platelet count. Recurrence In TP cases, recurrence was seen in 20% cases, but it is the result of very small data(5/151), so it may not have any significance.If we analyze base line Platelet count (PC), it is noticed that higher count cases have shown more percentage of recurrence. With PC 1-2 Lakh/cumm, recurrence is seen in 11.1%, PC 2-3 Lakh/cumm, it is 33.3%; thrice the value of previous one. It grossly appears to be statistically significant. PC between 2-3 lakh/cumm & between 3-4 lakh/cumm, no significant difference is being seen. It is 33.3% and 30.00% respectively.Now if we analyze recurrence rate with PC >4 lakh/cumm cases, it is around 60%, which is statistically significant. Mortality 13/151 cases expired within 4 years of treatment. 60% of these expired cases had platelet count >3lakh/cumm. Conclusion* Study shows that platelet count is directly proportional to the prognosis of cases of ovarian cancer.