Sustained release diclofenac sodium microcapsules were prepared using polymerized rosin as a novel wall-forming material by a solvent evaporation technique. A novel method developed in our laboratory with the potential for scale-up and production of polymerized rosin microcapsules is detailed. These microcapsules might have application for development of implant/depot systems, primarily due to a sustained/controlled release capability and potential biocompatibility of polymerized rosin. The effect of variables like solvent systems, stirring speed and temperature were previously optimized. The solution system of drug and polymerized rosin dissolved in iso-propyl alcohol and acetone is sprayed with the help of a 0.5 mm nozzle spray gun in liquid paraffin maintained at 60 degrees C in the stirring condition. Varying drug:polymer ratios, namely 1:1, 1:2, 2:1, 1:3 and 3:1, were employed for microcapsule preparation. The prepared microcapsules were evaluated for size, shape, drug content and in vitro drug release. The morphology of microcapsules was characterized by scanning electron microscopy. The microcapsules show sustained release curves at pH 7.4 phosphate buffer for up to 10 h. The data obtained from the dissolution profiles were compared in the light of different kinetics models and the regression coefficients were compared. The in vitro dissolution study confirmed the Higuchi-order release pattern. Particle size and release data analysis from five consecutive batches prepared in the laboratory indicated suitable reproducibility of the proposed solvent evaporation process.

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The objective of the present work was to develop and optimize ketorolac loaded controlled release tablet using a natural polymer. In this study, we utilized a combination of two natural polymers like Almond gum and guar gum to prepare Ketorolac controlled release tablets. The natural polymers are used in controlled release tablets because has numerous advantages and it is occurs naturally, relatively safe, cheap and do not have any side effects. Ketorolac controlled release tablet were prepared by direct compression method. First Pre-formulation studies were carried out such as FTIR, solubility, bulk and tapped density, housners ratio, Carr’s index, angle of repose etc. Then the tablets were prepared by direct compression using natural polymers. To obtain the desired optimum formulation several formulations had been performed with different excipients and their ratio. For each formulation, post formulation parameters are determined including hardness, weight variation, friability, disintegration and in vitro dissolution, etc. From the test performed it is found that the formulation F3 is best and satisfies all the criteria as controlled release tablet.