Summary1. Six young male volunteers were exposed to sarin vapour (isopropyl methyl phosphonofluoridate) at a concentration of 0-5 mg/rn3 for 30 min (concentration time (Ct) 15 (mg min)/m3). 2. The resulting clinical syndrome was treated by instilling 006 ml of a 1% solution of cyclopentolate into the conjunctival sac. 3. Visual acuity, retinoscopy, objective and subjective refraction and pupil sizes were noted before the trial, after exposure to sarin and after treatment with cyclopentolate.

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. A field trial was conducted in order to assess the effect upon tasks, including hard labour, skilled work, the use of instruments and tools and shooting, of giving 6 mg of atropine sulphate by injection to twenty‐three adult male volunteers. . Impairment of performance was seen in these tasks under the influence of the drug, but this was statistically significant only in some of them. . Drowsiness occurred in twenty‐one men and perceptual disorders were common, but two men were almost completely resistant to the effects of the drug. . The implications of the therapeutic use of comparable doses of atropine are discussed.