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No abstract

67 (1971). (17) Edinburgh Staff, "Pharmacological Experiments on Isolated Preparations," 1st ed, Livingstone, Edinburgh, pp 13-63. (18) G.

A series of N-methyl, N-(2-chloroethyl) and N-propargyl urea and nitrosourea derivatives of amino acids were synthesized and tested for anti-HIV and anti-proliferative activity. All the agents tested showed only a weak activity to counteract the cytopathic effects of the HIV-1 virus on a T4 lymphocyte cell line (CEM-IW). At high concentration, the N-methyl and N-propargyl ureas were cytotoxic. The nitrosoureas failed to suppress cell proliferation of uninfected CEM-IW cells. The lack of activity and cytotoxicity of the nitrosoureas in this model could be explained by their short chemical half-life.

A number of N,N-dialkyl-3-phenylpropyn-2-amines 7 have been prepared and tested for their biological action. Certain analogues show tryptamine-like behavior effects in mice. The tryptamine-like activity of these compounds appears to be controlled by their lipophilicity. These compounds show only weak inhibition of rat liver monoamine oxidase. Although these compounds exhibit tryptamine-like action, experiments seem to indicate that there is no interaction with the tryptamine receptors.