best compromise found was a 10% amitriptyline cream made in Versatile with urea at 2% as an emollient agent. This cream retains its diffusion properties, its organoleptic characteristics but also its physicochemical and microbiological stability for more than 6 months (stability data are still ongoing) in a PVC/ALU packaging.81 patients were included (February-November 2020). For 49 patients (60.5%), the cream was effective. The etiologies for which the cream seems to be the most effective are postchemotherapy pain (64% efficiency with taxane-based chemotherapy, 70% efficiency with platinum-based chemotherapy). Conclusion and relevanceThe development of this topical has allowed neuropathic patients to gain relief. These data are very encouraging and will be confirmed through the implementation of a clinical trial.