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Schrader (1947a), working on the preparation and insecticidal evaluation of certain phosphorus and fluorine compounds, developed some that were shown to be systemic. A systemic compound is one that is absorbed by the plant and translocated in the sap so that parts of the plant other than those treated become toxic to sucking insects. Schrader referred to these substances as agents for the chemotherapy of living plants. One of them was bis(bis dimethylamino phosphonous)anhydride, which was prepared by him in 1942 and shown by Kiikenthal (in Schrader, 1947a) to possess systemic properties. Dr. H. Martin (1947) called attention to these interesting compounds, pointing out (1949) that in regard to toxic hazards, bis (bis dimethylamino phosphonous)anhydride seemed more promising as an insecticide than some of the fluorine compounds.At Dr. Martin's suggestion, a comprehensive investigation was undertaken to examine the entomological, physico-chemical, chemical, plant physiological and toxicological properties of this anhydride in order to assess the potentialities of systemic insecticides as represented by it. This investigation included a study of the toxic risks involved and the necessary measures to overcome them. The project was begun in 1947 and was carried out by the following workers :-Biological Research: L. A. Lickerish, M.A., B.Sc.; E. G. Goscombe, B.Sc.;

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