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The present study introduces an active macroscopic mixing device for aqueous sanitizer preparation. It operates on a piezoelectrically actuated oscillating cantilever beam appropriate for disparate feature liquid–liquid mixing. A piezoelectric actuated cantilever beam at the third bending mode vibration frequency produces extreme vibrations when excited by a suitable voltage. Potent mixing occurs as the robust vibration energy is sent from the beam to the container’s test liquid. In this work, different glycerol concentrations were mixed with deionized (DI) water and ethanol at 25 ℃. The mixer’s performance to mix DI water–glycerol, ethanol–glycerol, and DI water–ethanol–glycerol considered a sanitizer was tested. The sanitizer mixture’s measured density, viscosity, and surface tension values were 0.7502 g cm −3 , 1.8906 cp, 34.7893 dyne cm −1 , respectively. The measured aqueous-based glycerol mixture’s density and viscosity values were validated with the computed values by previous researcher’s models and formulas. The observed density reading of the aqueous-based 25% glycerol concentration mixture agreed with the estimated value of a density model having ± 1.1290% deviation. Supplementary Information The online version contains supplementary material available at 10.1007/s11696-021-01886-3.