Introduction: For the study's purposes, the researchers are looking to examine if there is a correlation between the skeletal base connection and lip and dermal prints, as well as whether there is a significant variation between genders. Materials and Procedures: Participants in the study numbered 120: Based on Reidel's Malocclusion categorization, There were 40 each of Class I, Class II, and Class III samples. The cellophane technique was used to obtain lip, finger, and palm prints from each of the 120 participants, and the data was analysed using SPSS 22.0. Intergroup comparisons were made using the Chi square test. Atd angle and a-b ridge count were both shown to be statistically significant via the use of an ANOVA test. Class III skeletal malocclusion individuals have a vertical lip pattern, as opposed to the branching lip pattern seen in Class I and II. All three research populations, including the South Indian population, have a right loop pattern. Class I individuals exhibited a greater number of a-b ridges and a greater atd angle. The majority of males and females had branching lip patterns. Conclusion: Dermatoglyphics and cheiloscopy can be used to investigate the genetic correlations of malocclusion and to prevent malocclusion at an early stage. They are simple, affordable, and noninvasive. However, they are not totally dependable because to other ethnic and environmental factors.