Cyclic voltammetry and constant current electrolysis studies of SOCIs/ LiAlC14 solutions showed that SOeCI~, SOCI+AICI4 -, SC12, AICI~, and C12 are produced as oxidation products. Mechanisms of oxidation reactions are proposed to explain the formation of these products. Forced overdischarge of cathode limited cells produces Li2S which reacts with LiAICl4 present in the cell to form LiAISC12. Materials formed in anode limited cells during forced overdischarge include SOsCI2, SC12, C12, SOCI+AICI4 -, AIC13, and a substance with infrared absorption at 1070 cm -I. "Charging" of Li/SOCI2 cells involves regenerative processes so that only small amounts of products accumulate in the cell. * Electrochemical Society Active Member.

Tetrahydrofurans methylated in the α‐position manifest remarkable chemical and electrochemical stability toward Li. While tetrahydrofuran (THF) distilled off benzophenone ketyl and stored with Li at 71°C reacts in two days, 2‐methyltetrahydrofuran (2‐Me‐THF) treated similarly was stable for over 10 months. Electrolytes comprising either 2‐Me‐THF or 2,5‐dimethyltetrahydrofuran (2,5‐di‐Me‐THF) were subjected to cycling studies in half‐cell configurations. Average Li on Li cycling efficiencies exceeded 96% for Q=1 C/cm2 . Unlike the α‐methylated ethers, 3‐methyltetrahydrofuran (3‐Me‐THF) was as reactive towards Li as THF. Thus, the position of the methyl substituent with respect to the cyclic ether's oxygen atom is critically important, and several mechanisms are considered.

Die vorliegende Arbeit gibt einen umfassenden Uberblick uber den gegenwartigen Stand bezuglich des Einsatzes von Polymeren in der pharmazeutischen Technologie. Die Vor-und Nachteile von naturlichen und synthetischen Polymeren werden aufgezeichnet, und die laut unserem Arzneibuch geforderten Prufungen werden erlautert. Im Detail werden die fur die einzelnen Arzneiformen verwendeten Polymere vorgestellt. Es wird gezeigt, wie durch Polymere die Wirkung von Arzneimitteln gezielt beeinfluljt werden kann. IIoAuaepb, rcarc scno~omamenbnwe cpeacmea e gfiapaayeemuwcrcoii mexnonoeuuHacToHIqaR p a 6 o~a OIIEICbIBaeT COBpeMeHHOe COCTORHEIe IIpEIMeHeHEIR IIOJIHMepOB B &IpMaqeBTWieCKO# TeXHOJIOrAA. OqeHUBaIOTCR IIpeHMylqeCTBa EI HeROCTaTKU HaTypaJIbHblX CEiHTeTUqeCKEIX IIOJIMMepOB, a TaHme COrJIaCHO @apMa-KOIleU HeO6XOAUMhIe TeCTbI. DeTaJIbHO IIpeACTaBJIeHbI IIOJIEIMepbI, HCIIOJIb3yeMbIe AJIR KOHKPeTHhIX JIeKapCTB. nOIGlaaH0, KBK OTAeJIbHbIe IIOJlEIMepbI MOrYT 6bITb WCIIOJIb30BaHbI AJIR qeJIeHaIIpaBJIeHHOr0 BJIEIRHEie H a ,ge#CTBUe JIeHapCTBeHHbIX IIpeIIapaTOB. The use of polymeric auxiliary products in pharmaceutical technologyThe present state of the use of polymers in the pharmaceutical technology is reviewed. The advantages and disadvantages of natural and synthetic polymers are displayed and standard tests for pharmaceuticals are discussed. Some polymers which are used in different types of drugs are presented in detail. It is shown how the action of drugs can be affected by polymers.

No abstract

Cyclisch voltammetrisch sowie durch Elektrolyse bei konstantem Strom werden SO2Cl2, SOCl+AlCl4‐, SCl2, AlCl3 und Cl2 als Oxidationsprodukte in SOCl2/LiAlCl4 ‐Lösungen nachgewiesen.