Berkowitz, Ari, Gina L. C. Yosten, and R. Mark Ballard. Somatodendritic morphology predicts physiology for neurons that contribute to several kinds of limb movements. J Neurophysiol 95: 2821-2831, 2006. First published February 1, 2006 doi:10.1152/jn.01246.2005. It has been difficult to predict the behavioral roles of vertebrate CNS neurons based solely on their morphologies, especially for the neurons that control limb movements in adults. We examined the morphologies of spinal interneurons involved in limb movement control, using intracellular recording followed by Neurobiotin injection in the in vivo adult turtle spinal cord preparation. We report here the first description of a class of spinal interneurons whose somato-dendritic morphologies predict their robust activity during multiple forms of ipsilateral and contralateral fictive hindlimb scratching and fictive hindlimb withdrawal. These "transverse interneurons" or T cells have a mediolaterally elongated soma and a simple dendritic tree that is extensive in the transverse plane but restricted rostrocaudally. During fictive scratching, these cells display strong rhythmic modulation with higher peak firing rates than other scratch-activated interneurons. These higher peak firing rates are at least partly caused by T cells having larger phase-locked membrane potential oscillations and narrower action potentials with briefer afterhyperpolarizations than other scratch-activated interneurons. Many T cells have axon terminal arborizations in the ventral horn of the spinal cord hindlimb enlargement. Identification of this morphological and physiological class of spinal interneurons should facilitate further exploration of the mechanisms of hindlimb motor pattern selection and generation.

The growing use of herbal dietary supplements (HDS) in the United States provides compelling evidence for risk of herbal-induced liver injury (HILI). Information on HDS products was retrieved from MedlinePlus of the U.S. National Library of Medicine and the herbal monograph of the European Medicines Agency. The hepatotoxic potential of HDS was ascertained by considering published case reports. Other relevant data were collected from governmental documents, public databases, web sources, and the literature. We collected information for 296 unique HDS products. Evidence of hepatotoxicity was reported for 67, that is 1 in 5, of these HDS products. The database revealed an apparent gender preponderance with women representing 61% of HILI cases. Culprit hepatotoxic HDS were mostly used for weight control, followed by pain and inflammation, mental stress, and mood disorders. Commonly discussed mechanistic events associated with HILI are reactive metabolites and oxidative stress, mitochondrial injury, as well as inhibition of transporters. HDS–drug interactions, causing both synergistic and antagonizing effects of drugs, were also reported for certain HDS. The database contains information for nearly 300 commonly used HDS products to provide a single-entry point for better comprehension of their impact on public health.