IMPORTANCE Anhedonia, a reduced capacity for pleasure, is described for many psychiatric and neurologic conditions. However, a decade after the Research Domain Criteria launch, whether anhedonia severity differs between diagnoses is still unclear. Reference values for hedonic capacity in healthy humans are also needed. OBJECTIVE To generate and compare reference values for anhedonia levels in adults with and without mental illness.

Title: Heat but not mechanical hypersensitivity depends on voltage-gated Ca V 2.2 calcium channel activity in peripheral axon terminals innervating skin Abbreviated title: Peripheral Ca V 2.2 channels control heat hypersensitivity