Background: The motive behind conducting this study was to determine if better control of asthma can be achieved by adding a second controller medication and to assess its use to reduce the dose of inhaled steroids. Objectives: The study aimed to determine whether either oral sustained-release theophylline or montelukast added to inhaled steroids improved clinical symptoms and pulmonary function test parameters when compared to high-dose steroids alone. Methods: Ninety patients with incompletely controlled asthma were allocated, in a randomised, double-blind fashion, to one of three treatment groups: group A: double dose of inhaled budesonide (400 µg b.i.d.), group B: 400 mg oral sustained-release theophylline plus budesonide (200 µg b.i.d.) and group C: 10 mg montelukast plus budesonide (200 µg b.i.d.). The primary endpoints were forced expiratory volume in 1 s (FEV1) and mean morning peak expiratory flow rate (PEFR). Results: All three groups had improved FEV1 and PEFR at 8 weeks (p < 0.001). Group C increased their PEFR by 18.7 l/min (95% confidence interval, CI, 12.4–25.1) more than group A and by 19.8 l/min (95% CI 13.4–26.1) more than group B (both p = 0.001). Similarly, group C had a 114 ml (95% CI 45–183 ml) greater improvement in FEV1 than group A and a 95 ml (95% CI 26–164 ml) greater improvement than group B (both p = 0.01). Conclusions: Addition of montelukast to budesonide is safe and results in greater improvement in pulmonary function test parameters than high-dose budesonide treatment or addition of theophylline.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2025 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.