Background: Generation of novel spontaneous ER positive mammary tumor animal model from heterozygous NIH nude mice.

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Acute otitis externa is a common clinical condition that presents with rapid onset of otalgia, fullness, otorrhea and canal oedema. Moisture in-ear canal appears to be an important predisposing factor. The most common etiological agents include Pseudomonas aeruginosa and Staphylococcus aureus. Management includes control of otalgia and elimination of infection from the ear. Precipitating factors should be avoided. The main objective of this study is to compare the efficacy of 10% ichthammol glycerol ear pack with steroid antibiotic ear pack in the treatment of acute otitis externa. Institutional Review Board (IRB) clearance was obtained, and a prospective randomised clinical trial was conducted in the ENT outpatient department of Saveetha Medical College & Hospital, Thandalam, from January 2020 to March 2020. Patients were explained about the study in detail, and consent was obtained. The patients were randomised, and 10% ichthammol glycerol pack and steroid antibiotic pack were used in alternate turns for aural packing. Pain rating was done using Numerical rating scale (NRS) before and 48 hours post-treatment and also in each subsequent hospital visit till complete subsidence of symptoms. Among the 85 patients included in the study, 42 (49.4%) were males, and 43 (50.6%) were females. Most of them belonged to the age group 31-40 years (41.2%). Tragal tenderness and external auditory canal oedema were the most common ear findings noted. In the patients treated with steroid antibiotic pack, only 2.3% of the patients had severe pain, whereas 14% had moderate pain and 83.7% had only mild pain. Whereas among those treated with 10% ichthammol glycerol pack, 9.5% of the patients had severe pain, whereas 35.7% had moderate pain and 54.8% had mild pain. On analysis, the results were statistically significant, and there was considerable pain relief with steroid antibiotic pack. Therefore, our study showed that steroid antibiotic pack is more effective in relieving the symptoms, thereby reducing the number of hospital visits when compared to 10% ichthammol glycerol pack.

The present study investigates the presence of phytochemical compounds in the ethanol and methanol extract of Curculigo orchiodes, it was elucidated using Gas chromatography-Mass spectrometry. Qualitative phytochemical compounds of both extracts reveal the presence of flavonoids, tannins, phenol, protein, cardiac glycosides, terpenoids, and carbohydrate and have a higher level compounds in ethanol extracts of C.orchiodes. Fifteen bioactive phytocompounds were identified in the ethanol and methanol extract of C.orchiodes. GCMS reveal the presence of 2-Furanmethanol, Cyclopentanone, 2-Methyl, Formic acid, 2-Propenyl ester, 2,5-Furandione, 3-Methyl, phenol 3-Methoxy-, 2-Methoxy-4-vinyl phenol, 1,2-Benzenediol, 3-methoxy-, n-Hexadecanoic acid and phytol which has medicinal property such as antibacterial, antiviral, anticancer and antioxidant. C.orchiodes was assayed for antibacterial activity against the tested microorganisms such as Escherichia Coli, Klebsiella Pneumonia, Pseudomonas aeruginosa using well diffusion method. Ethanol extract show the highest zone of inhibition ranging from 3.4±0.200 to 5.28±0.350 compared with standard antibiotics. From this study, results highlight that the ethanol extract of C.orchiodes will be a valuable source for the production of herbal medicine and maintaining human health.

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