No abstract

The hydrolytic behavior of monolayers of biodegradable [poly(l-lactide)/poly( -caprolactone)] (l-PLA/ PCL) blends spread at the air/water interface is studied to identify the relative rate of hydrolytic degradation of each component when exposed to a basic subphase. As the hydrolysis time increases, the isotherm recorded from (l-PLA/PCL) blend monolayers was found to be similar to that of PCL homopolymer; this is likely due to the preferred hydrolysis of l-PLA. The rate of hydrolysis was recorded by a change of occupied area when the monolayer is maintained at a constant surface pressure. The hydrolysis of the blend in a basic condition was much faster than that of each homopolymer, regardless of the composition, arising from a dilution effect on the concentration of l-PLA monolayers. From the deviation behavior (D) between the arithmetic average and experimental values, blends with compositions less than 50 mol % l-PLA showed the maximum dilution effect (Dt ) 0.11t, where t is hydrolysis time) whereas high l-PLA compositions (g75 mol % l-PLA) showed a smaller effect.

No abstract

The controlled release of growth factors from porous, polymer scaffolds is being studied for potential use as tissue-engineered scaffolds. Biodegradable polymer microspheres were coated with a biocompatible polymer membrane to permit the incorporation of the microspheres into tissue-engineered scaffolds. Surface studies with poly(D,L-lactic-co-glycolic acid) [PLGA], and poly(vinyl alcohol) [PVA] were conducted. Polymer films were dip-coated onto glass slides and water contact angles were measured. The contact angles revealed an initially hydrophobic PLGA film, which became hydrophilic after PVA coating. After immersion in water, the PVA coating was removed and a hydrophobic PLGA film remained. Following optimization using these 2D contact angle studies, biodegradable PLGA microspheres were prepared, characterized, and coated with PVA. X-ray photoelectron spectroscopy was used to further characterize coated slides and microspheres. The release of the model protein bovine serum albumin from PVA-coated PLGA microspheres was studied over 8 days. The release of BSA from PVA-coated PLGA microspheres embedded in porous PLGA scaffolds over 24 days was also examined. Coating of the PLGA microspheres with PVA permitted their incorporation into tissue-engineered scaffolds and resulted in a controlled release of BSA.

No abstract