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Conclusion:JGCOT generally occurs during childhood. The primary management of JGCOT is through surgery. The role of adjuvant therapy is controversial. Because survival is long at early stages and most of the patients are young, fertility sparing surgery could be safely suggested to these patients. (J Turk Ger Gynecol Assoc 2015; 16: 32-4) Keywords: Juvenile granulosa cell tumor, ovary, adjuvant therapy, fertility sparing surgery Received: 01 November, 2014 Accepted: 30 December, 2014 Juvenile granulosa cell ovarian tumor: clinicopathological evaluation of ten patients

IntroductionThe vanishing cancer phenomenon was first described by Goldstein in 1995 (1), who described two cases in which no residual carcinoma was present in radical prostatectomy specimens. Both cases involved low-grade and early stage disease with low-volume tumors in the biopsy specimens. The authors proposed that the possible reasons for vanishing cancer in biopsy proven specimens as early detection of prostate cancer in asymptomatic men (2,3) and a larger number of low-stage cancers being treated by prostatectomy. In early stage and low volume tumors (<0.01 cc), determining the residual microscopic tumor in the radical prostatectomy specimen is challenging for the pathologist. After 1995, more researchers reported increasing numbers of vanishing cancers in radical prostatectomy specimens with a prevalence of 0.07%-0.67% (1-5).Background/aim: The vanishing cancer phenomenon was first reported in radical prostatectomy specimens in the absence of neoadjuvant treatment. Reported cases are mostly well-differentiated and low-volume tumors. A similar entity was described for hysterectomy specimens of patients with biopsy proven endometrial cancer (EC). In this study, we discuss the probable reasons for vanishing EC and long-term follow-up results of EC patients without residual tumors in hysterectomy specimens. Materials and methods:This study was carried at two institutions in Ankara, Turkey, in a retrospective design. The computerized databases of both institutions were searched for endometrioid type EC patients whose final pathological specimens failed to show any residual tumor. Results:We evaluated 38 endometrial biopsy confirmed EC patients with no residual tumor detected in the hysterectomy specimens among a total of 224 women (17%) with the disease confined to the endometrium. During the follow-up period, no recurrences were noted among the patients. Conclusion:It can be suggested that premenopausal women with FIGO grade 1 endometrioid type EC with MRI proven "absent myometrial invasion" would have a significant probability of having no residual tumor after endometrial biopsy without any further medical treatment.

We report a case of pericardial effusion induced by methotrexate in a patient with low risk gestational trophoblastic neoplasia, who had been taking the first course of sequential methotrexate-folinic acid treatment. After aspiration of pericardial effusion another methotrexate-folinic acid course was given and the pericardial effusion did not relapse.