Breast carcinoma is a common malignancy among women and the most common of complications associated with modified radical mastectomy is the formation of seroma. Various methods have been tried to reduce the incidence of seroma formation. This study aims to study effect of fixation of flaps using sutures in reduction of drain amount and duration of drain placement. 200 female patients who underwent modified radical mastectomy were divided to two groups, study group underwent flap fixation and control group had conventional flap closure. Average number of days of drain among the experimental group was 12.3+/-2.4 and that among the controls was 18.4+/-2.5 (p<0.001). The total amount of drain was 875+/-490 ml in control group as compared to 670+/-270 ml in fixation group (p<0.05). Thus it is seen that flap fixation using sutures is and effective method to reduce the total amount of drain output and duration of drain and thus the seroma formation.