An efficient iron/acetic acid mediated one pot reductive cyclization protocol was successfully developed for the synthesis of acridinone and quinoline derivatives.

Iron/acetic acid mediated synthesis of 6,7-dihydrodibenzo [b,j] [1,7]phenanthroline derivatives via intramolecular reductive cylization An efficient iron/acetic acid mediated intramolecular reductive cyclization protocol for the synthesis of novel 6,7dihydrodibenzo[b,j][1,7] phenanthroline derivatives is described. In this two-step procedure, aldol addition and 10 reductive cyclization methods are effectively utilized for the construction of C-C and C-N bonds. This highly efficient process proceeds under mild conditions, tolerates different functional groups, and provides various substituted 6,7dihydrodibenzo [b,j] [1,7]phenanthroline derivatives in good 15 to excellent yields. In addition, various synthetic utilities of these derivatives are also described.

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A protocol for the N-bromosuccinimide (NBS)- and trichloroisocyanuric acid (TCCA)-mediated synthesis of novel 2-halomethylene-3-oxoketoximes via one-pot halogenation/oxidation of isoxazoline N-oxide derivatives is described here. The keto functionality of 3-ketoximes was selectively reduced by lithiumaluminum hydride to synthesize an unprecedented type of Baylis-Hillman oxime, which underwent N-O coupling to produce new isoxazoline N-oxide derivative.

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