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Sarcoma 180 and Ehrlich carcinoma maintained in the ascitic form were transplanted subcutaneously, intraperitoneally and intracerebrally. The same tumor transplanted in different sites showed a different sensitivity to the same chemotherapeutic agent. Cyclophosphamide and sarcolysin were active on subcutaneous and intraperitoneal, but not on the intracerebral tumors. On the other hand, I-methylnitrosourea was effective only on the tumors transplanted intracerebrally.Previous work from this laboratory showed the possibility of implanting sarcoma 180 and Ehrlich adenocarcinoma into the brain of mice (Rosso et al., 1967). Having available the same experimental tumor transplanted in three different sites, i.e. subcutaneously, intraperitoneally and intracerebrally, it was of interest to investigate if a given antitumoral drug was able to show any selective effect. This paper reports the results obtained with sarcolysin, cyclophosphamide and 1-methylnitrosourea. The latter drug has been previously found effective on leukemia L 1210 (Goldin et al., 1964) and on T8 uterine epithelioma (Rosso and Palma, 1966) transplanted intracerebrall y .

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