The purpose of the study was to study the effect of polyphenols (curcumin, epigallocatechin-3-gallate, and quercetin) on indicators of lipid peroxidation and antioxidant protection in the submandibular salivary glands of rats with alcohol damage against the background of lipopolysaccharide-induced systemic inflammatory response. Materials and methods. The studies were conducted on 35 rats of the Wistar line weighing 205–220 g, divided into 5 groups of seven animals in each: the 1st group (control) included animals receiving isotonic sodium chloride solution intragastrically twice a day; the 2nd group included rats exposed to alcohol (in a dose of 24 mg/kg intragastrically through gavage twice a day) for last 2 weeks during lipopolysaccharide-induced systemic inflammatory response; the rats of the 3rd, 4th and 5th groups were exposed to alcohol during lipopolysaccharide-induced systemic inflammatory response, which also received polyphenols, administered intragastrically: curcumin (diferuloylmethane, in a daily dose of 200 mg/kg), epigallocatechin-3-gallate (in a daily dose of 40 mg/kg), quercetin (in a daily dose of 200 mg/kg), respectively. The level of lipid peroxidation in the tissues of the submandibular salivary glands was assessed by the formation of compounds that react with thiobarbituric acid. The state of antioxidant protection was assessed by the increase in the concentration of thiobarbituric acid-active products during a 1.5-hour incubation in iron ascorbate buffer solution, as well as by the activity of superoxide dismutase. Results and discussion. When using curcumin under the experimental conditions, the concentration of thiobarbituric acid-reactants in the homogenate of submandibular salivary glands before and after incubation was 59.3 and 55.7% inferior to the corresponding results of the 2nd group, when prescribing epigallocatechin-3-gallate – by 55.7 and 51.2%, quercetin – by 67.0 and 61.0%, respectively. This was accompanied by a probable increase in the activity of superoxide dismutase in the tissues of the submandibular salivary glands. Conclusion. The use of curcumin and bioflavonoids (epigallocatechin-3-gallate and quercetin) under conditions of combined administration of 40% ethanol and S. typhi lipopolysaccharide significantly limits the development of lipid peroxidation in the tissues of the submandibular salivary glands, increases their antioxidant potential, superoxide dismutase activity