Currently, according to WHO, at least 70% of drugs on the world market are duplicates or are not vital drugs. A number of drugs have an unfavorable balance of risk and effect. According to indications, many new drugs do not meet the basic needs of the majority of the population; they are much more expensive than existing drugs. A stable trend in recent years on a global scale is an increase in the cost of drugs, according to WHO experts, by an average of 20% per year, and those that are most often used by the majority of the population (antiulcer, antihypertensive drugs and antibiotics) [1]. In such conditions, the problem of rational use of drugs becomes extremely urgent. In daily practice, doctors need to make the choice of a drug for a particular patient, thereby ensuring the maximum therapeutic effect at a reasonable cost. This choice of medicinal product must be scientifically based.

The drug supply system in the Republic of Tatarstan includes 298 pharmacies of the State Enterprise "Tatarstanpharmacy". Along with state structures, pharmacies of the private healthcare system appear, engaged in the manufacture and sale of medicines and medical products. In the absence of a law on medicines, in order to protect the interests and rights of the population of Tatarstan to provide high-quality pharmaceutical products and maintain the necessary volume of drug services, a resolution of the Cabinet of Ministers of the Republic of Tatarstan introduced licensing of pharmacy institutions for the right to manufacture, store, transport medicines and medical products , which was the first step in the system of legal regulation in this area.

In connection with significant structural changes in the Republic of Tatarstan associated with market transformations and a deficit of budgetary funds, providing the population with medicines and medical products on preferential terms is one of the problems that have sharply aggravated in recent years and have thus become of major social importance. Currently, more than 1 million people enjoy the right to preferential purchase of medicines in the Republic of Tatarstan.

Aim. To ground the necessity of taking into account the double-component nature of the phenomenon of poor activity of the population in the system of pharmacovigilance so as to work out the measures, aimed at development of UR reporting. The process of formation of a modern system of pharmacovigilance in Russia with appropriate level of reporting on the cases of unfavorable response (UR) to application of drugs is difficult because of the absence of involvement of the population into the system of spontaneous messages. Materials and methods. The methods of content-analysis of messages and surveys were used; the measures, promoting development of the level of reporting on unfavorable responses to drugs were worked out. The object of the analysis included randomized sampling of 100 tests of messages for the period of 2009–2017, the selection criterion of which was the category “side effects of drugs”. The survey was conducted in direct form among the inhabitants of Kazan in 2018. Results. Pharmacovigilance of the population in Russia is insufficiently developed and concentrated mainly in metropolitan region (Moscow, Moscow region) and neighboring regions (Republic of Tatarstan, St. Petersburg). Pharmacovigilant culture of the population in Russia has an insufficient level of development and is expressed by lack of correct notions of pharmacovigilance system in this country (responsible state institutions, reporting channels) among the citizens that, probably, makes their participation in active reporting difficult. Conclusions. When influencing both factors, we can form the basis for working out the measures of efficient development of the proper level of UR reporting among the population of the Russian Federation.

To improve the provision of drugs to the population and medical institutions, it is necessary to have a fairly complete picture of their need for drugs, which is clearly related to the incidence of the population. We studied the statistical data on the incidence of the population of the Republic of Tatarstan from 1990 to 1993. As the analysis showed, the total number of registered diseases, including those with a first diagnosis, increased in 1993 by 7.3% and 6%, respectively, compared with the figures in 1990 (see table). The actual number of cases exceeds the estimated number of reported cases by approximately 30%, due to under-reporting.