AZD1222 (Covishield) COVID-19 vaccination response among healthy adults and chronic renal disease patients has been compared in this analysis. Compared to healthy individuals, vaccine induced immune response seems to be suboptimal after two doses of the vaccine in patients with chronic renal disease on hemodialysis. Infection following full course of vaccination can boost the vaccine induced antibody levels in both healthy individuals and patients with chronic renal disease.It is necessary to conduct comprehensive prospective research to further evaluate these conclusions made based on this preliminary data evaluation, and to find out its overall impact for future SARS-CoV-2 infection and its disease outcome.