The effect of a fruit (apple)-enriched diet on bile secretion and on fecal steroid excretion was studied in two strains of hamster: normal hamsters with normal cholester-olemia and spontaneous hypercholesterolemic hamsters with high-level hepatic cholesterol esters (FEC hamsters). Quantitative and qualitative alterations in the steroid composition in bile and feces were accompanied by changes in intestinal morphology. The fruit diet displayed a choleretic effect and increased the output of bile acids from liver in FEC hamsters. In addition, bile collected continuously from cannulated apple-fed animals was enriched with conjugates of cholic acid. Moreover, apple consumption lowered the lithogenic index of the bile. In response to the fruit diet, fecal excretion of bile acids and neutral sterols increased, essentially in the form of primary bile acids and sterol esters, respectively.

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Many allopathic medicines demand to remedy for hypertension but fail to fulfill the purpose, because of side effects and high cost. Herbal medicine does not cause side effects and natural herbs are completely safe. Rational and purpose of this study was to see how effective Uraria picta. Jacq. (U.P) extract was on experimentally induced hypertension in rats. The purpose of this research was to explore if U. Picta could be utilized as a curative or preventative medicine, as well as to investigate U. Picta possible toxicity in these animals. Blood pressure was elevated by Angiotensin II (150 ug/kg, i.p) in rats that is hypertensive condition. Animals were divided into groups as follow Group I (control) - vehicle, Group II Angiotensin II (150µgkg), Group III Angiotensin II extract low dose (100mgkg), Group IV-Angiotensin II extract middle dose (200mgkg), Group V-Angiotensin II extract (400mg/kg), Group VI – (Angiotensin II Telmisartan0.8mg/kg). and dosed as per protocol. Blood pressure was monitored with the noninvasive techniques (NIBP) using Power lab (AD instrument) Australia. Effect of extracts was studied on various oxidative stress markers like SOD, CAT, LOP and NO. as per observation extract of U. picta of high dose (400mg/kg BW p.o) had shown significant alteration in endogenous antioxidant entities i.e., SOD, CAT, LPO and also reduced NO level indicate antioxidant property of U. Picta. Same of above dose also reduced blood pressure and ACE level. So, from the above outcome we can consider that U.Picta extract may be having antioxidant and antihypertensive activity.