10,853 sera, collected from ‘healthy’ blood donors during the period December
1977 to May 1979, were tested for the presence of penicillinase-sensitive penicillins by a bioassay
technique using Bacillus subtilis ATCC 6633 as test organism. Their presence could be
demonstrated in 30 sera (0.27%), at concentrations equivalent to 0.2-4.0 µg/ml of penicillin G.
The implications of these findings are discussed, particularly the possibility of their relationship
to nonhemolytic adverse reactions to transfusion.
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