There are many Agada Yogas widely practiced by Visha vaidyas. Lodhra Sheethadi Agada is one of the practically used formulation in the management of Mandali Sarpa Visha. This formulation is explained in Visha Vaidya Jyotsnika, Prayogasamucchayam, Lakshanamritham etc. It consists of nine drugs in the reference given in Visha Vaidya Jyotsnika whereas ten ingredients in that of Prayogasamuchayam. This formulation can be administered as Paana as well as Lepa. The administration of Lodra Sheethadi Agada in Kasaya form is clinically practiced in present era. This paper is an attempt to review the yoga ‘Lodhra Sheethadi Agada’.

In Ayurveda literature, the poisonous snakes are classified under three categories. They are Darvikara (vata predominance), Mandali(pitta predominance), and Raajila (Kapha predominance). This classification is mainly based on their quality of visha. Snake poison has foremost importance among the jangama visha (animate poison) category as it is a condition which needs emergency management. The tradition of Agadatantra in Kerala is most developed and Ayurvedic toxicologists (VishaVaidya's) of Kerala considered seven famous treatises as their authentic reference books. Prayoga samuchayam is one among that. Multiple formulations which can be used for all types of poisoning cases were comprised in this.The "Urithookki tailam" formulation taken from this famous book and it covers only one drug, Iswari (Aristolochia indica). This formulation can be used as a confirmatory test as well as treatment of sarpa visha (snake poison). As soon as a patient who is bitten by a snake comes, apply 2-3 drops of the taila(oil) in a betel leaf, based upon the taste perceived by the patient, Vaidya differentiates the nature of Sarpavisha (Snake venom) and treat accordingly. Further research works on this preparation may prove the exact mode of action on the Sarpavisha (snake venom) and its use in the field of Ayurveda

Background: Vatsanabha is a potent cardiac poison comes under the category of Mahavisha with its main active principles aconitine, picraconine and pseudaconine. In the literatures there are descriptions about toxicants and in some traditional Malayalam textbooks antidotes has been explained under the concept “Prathyoushadha”. Neeli Moola has been mentioned as a Prathyoushadha for Vatsanabha poisoning in a renowned textbook „Visha Vaidya Jyotsnika‟. Hence to evaluate the antidotal activity in Vatsanabha poisoning, Neeli Moola Kalka has been used and the haematological parameters were analyzed to screen the results. Methods: Wistar strain albino rats were used in this study which were divided into 3 groups, normal control, toxic control and the test drug group. The duration of the study was 28 days .The data generated was mentioned as Mean±SEM. Difference among the groups was assessed by employing one way ANOVA followed by Dunnet‟s mul tiple „t‟ test. Results: Reversible action has been observed after the administration of Neeli Moola Kalka in the hematological parameters which has shown toxicity changes due to administration of Vatsanabha. Conclusion: Neeli Moola Kalka is having mild to moderate antidote effect in Vatsanbha induced toxicity.

Strychnine is a natural alkaloid obtained from the dried seeds of Strychnos nux vomica. It occurs as colourless, odourless, rhombic prisms, having an intensely bitter taste. The seeds contains about 1.1-1.4% strychnine. It is a spinal poison & the chief chemical constituent that accounts for the toxic manifestations and is 10 to 20 times more poisonous than brucine. Tonicclonic convulsions are the characteristic clinical manifestation seen in strychnine poisoning. Kupilu is one among the upavishas that comes under the category of sthavara visha. References regarding the drug kupilu are mentioned in the classical texts according to the time period. There is no reference of kupilu in vedakala and samhitakala and was not reported in the 'BrihatTrayee' texts of Ayurveda. In samgrahakala, the reference of visamusti as one of the ingredient of the formulation Agnitundirasa can be seen inSharngadhara samhita. Toxicity is the degree at which a substance can damage a tissue or organ. It can be acute, sub-acute and chronic. In the present study 5 groups were taken; group1-control, group2-ashodhita kupilu(1/5 th LD50), group3-ashodhita kupilu (1/10 th LD50), group4strychnine(1/5 th LD50) and group5-strychnine (1/10 th LD50). Significant results were observed in the 1/5 th LD50 strychnine received group when compared to ashodhita kupilu (1/5 th LD50) treated group.