This study provides the largest, so far, hypothesis-generating evidence for a putative positive risk/benefit ratio for treatment of obese patients with type 2 diabetes mellitus with the DJBL as an alternative treatment option for this patient population.

A 67-year-old male patient with typical signs of acrokeratosis Bazex is presented. The psoriasiform skin lesions appeared 9 months after diagnosis of an oesophagus neoplasm. Clinically there was a marked hepatopathy but no signs of metastases. Histological, immunofluorescence-histological, and ultrastructural findings revealed a capillaritis with humoral as well as cellular inflammation. With treatment of the neoplasm the paraneoplasia regressed under additional treatment with topical steroids. The vitamin A deficit could not be normalized by oral or parenteral vitamin A substitution. We discuss some mechanisms in formal pathogenesis.

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<b><i>Background:</i></b> Atopic dermatitis (AD) is a chronic skin disease characterized by dry skin, severe itching, inflammation and impaired quality of life. Moisturizing is an integral part of treatment for AD, but its potential for prevention of AD is unclear. <b><i>Objective:</i></b> To evaluate whether the early use of emollients in infancy can prevent later development of AD. <b><i>Methods:</i></b> We searched Medline, Embase, Web of Science, PubMed, Cochrane Library and other databases to collect randomized controlled trials on early use of emollients in infants for a meta-analysis. <b><i>Results:</i></b> Nine articles were included. The OR value for incidence rate was 0.7 (95% CI: 0.48–1.01). No significant publication bias was found by Egger’s test. The sensitivity analysis indicated that the final conclusion was reliable. <b><i>Conclusions:</i></b> We found that the difference in incidence rate of AD between the experimental and control groups was not statistically significant. However, due to different methods of using emollients, different follow-up times and different sample sizes included in this meta-analysis, a definitive conclusion could not be reached in this study. In the future, it is still necessary to carry out randomized controlled, multicenter, large-sample trials with an excellent study design and high methodological quality on early application of emollients in high-risk infants to prevent AD.

Subungual keratoacanthomas (SKA) differ in clinical presentation, biological behaviour and the therapy needed from keratoacanthomas in other localizations. Against the backdrop of two personal observations and a review of the literature, the authors describe clinical and histological features and also the differential diagnosis and therapy and this rare benign neoplasm. Patients present with a rapidly growing, painful subungual mass, which causes destruction of the underlying bone and usually does not regress spontaneously. Histological differentiation from squamous cell carcinoma is essential as the prognosis and treatment are different. SKA is treated by local excision and curettage. Erosions of the underlying distal phalanx usually heal spontaneously. However, persistent recurrences after subtotal excision often necessitate amputation of the distal phalanx.