A quasi experimental study to evaluate the efficacy of sesame oil on radiation induced xerostomia among patients with head and neck cancer. Non randomized quasi experimental pretest posttest control group design was adopted in this study. By using purposive sampling technique, 26 samples were selected based on inclusion criteria, 13 in experimental and 13 in control group. The demographic variables, clinical profile of the samples were collected, the level of Xerostomia was assessed by modified GRIX questionnaire in both experimental and control group. Intervention was given to experimental group and routine treatment was given to control group. It was identified that the mean level of Xerostomia among head and neck cancer patient in the experimental and control group was 51.08 and 30.4 respectively with mean difference of 20.54. Likewise the standard deviation of the experimental and control group was 4.63 and 4.92 respectively. The calculated ‘t’ value 10.96 was greater than the table value of 2.06 at 0.05 level of significance. Hence, it was concluded that sesame oil mouth rinsing is an effective method to reduce the radiation induced Xerostomia among patient with head and neck cancer.