People are implanted or clipped with orthodontic wires made of diverse materials in order to regulate the growth of teeth. When these orthodontic wires are exposed to the oral environment, by the influence of food intake, toothpaste, mouthwash and tablets, may undergo corrosion. The present study focus the evaluation of corrosion resistance action of orthodontic wires of Ni-Ti alloy immersed in artificial saliva in the absence and presence of Domperidone and Perinorm tablets. Polarization and AC impedance study reveals that the corrosion rate of the Ni-Ti alloy system in various solution decreases in the following order: Artificial Saliva > Artificial Saliva + Domperidone / Perinorm tablet. This is evidenced by gradual increase in Linear Polarization Resistance (LPR) and decrease in Corrosion Current (Icorr) by polarization studies then there is an increase in charge transfer resistance (Rct) and decrease in double layer Capacitance (Cdl) by AC impedance spectra. Scanning electron microscope imaging gave the morphological data for the sample; however using the Scanning electron microscope and Energy Dispersive Analysis of X-Rays the elemental composition was determined. Hence the present study concludes that people clip with orthodontic wire made of Ni-Ti alloy can take Domperidone / Perinorm tablets orally without any hesitation.