Ribotype 027 was found in 20 (18.3%) of 109 hospitals in The Netherlands, with a geographic concentration in the western and central parts of the country. The clinical syndrome in patients with CDAD differed on the basis of ribotype. Thus, early recognition of the ribotype has benefits.

Various measures for identifying the onset of babbling have been proposed in the literature, but a formal definition of the exact procedure and a thorough validation of the sample size required for reliably establishing babbling onset is lacking. In this paper the reliability of five commonly used measures is assessed using a large longitudinal corpus of spontaneous speech from forty infants (age 0 ; 6-2 ; 0). In a first experiment it is shown that establishing the onset of babbling with reasonable (95%) confidence is impossible when the measures are computed only once, and when the number of vocalizations are not equal for all children at all ages. In addition, each measure requires a different minimal sample size. In the second experiment a robust procedure is proposed and formally defined that permits the identification of the onset of babbling with 95% confidence. The bootstrapping procedure involves extensive resampling and requires relatively few data.

To explore the natural history of asthma and its relation to allergic responses, we examined the relation between total serum IgE in early adulthood and a history of respiratory symptoms, airway hyperresponsiveness (AHR), and atopy during childhood. We studied 180 subjects aged 18–20 years who had been studied since the age of 8–10 years. We measured wheeze in the previous year by questionnaire, AHR by histamine inhalation test, atopy by skin prick tests, and serum IgE levels by immunoassay. Subjects with AHR in early adulthood had higher IgE levels (mean 257.0 IU/ml) than subjects with past AHR (mean 93.3 IU/ml) or with lifelong normal responsiveness (mean 67.6 lU/ml) (P< 0.001). Subjects who had symptoms had higher IgE levels (mean 125.9 IU/ml) than those who were lifelong asymptomatic (mean 63.1 IU/ml) (P< 0.001). Recent wheeze, AHR, and allergic sensitization all had a positive relation to serum IgE, but IgE was not more predictive of AHR than skin prick tests. The finding that young adults who are sensitized to common allergens are highly likely to have AHR even in the absence of symptoms is further evidence of the fundamental role of IgE‐mediated responses in the natural history of AHR throughout childhood and into adulthood.

No abstract

Consonant inventories are commonly drawn to assess the phonological acquisition of toddlers. However, the spontaneous speech data that are analysed often vary substantially in size and composition. Consequently, comparisons between children and across studies are fundamentally hampered. This study aims to examine the effect of sample size on the resulting consonant inventories. A spontaneous speech corpus of 30 Dutch-speaking 2-year-olds was used. The results indicate that in order to construct and compare inventories reliably, they should be drawn from speech samples that are equally large. A new consonant inventory procedure is introduced. The implementation of this procedure demonstrates considerably less variation in inventory size across children and word positions than reported previously. This finding has important implications for clinical studies that constructed and compared inventories of typically and atypically developing children without normalizing the sample size.