Physiotherapists, Dieticians, and Exercise professionals have much better scope to become trailblazers in the forthcoming years to revamp the public health system and set spectacular trends in interdisciplinary health care for the people. Meanwhile, they must scrupulously engage in research pursuits and the dissemination of advanced knowledge in health and disease. A macrocosm of research literature in all the medical super-specializations are currently available but they would go futile if they are not unified and channelized for holistic and equitable health care. Human health is attained or maintained by acquiring homeostasis to coordinate and control a wide range of physiologic parameters within Narrow Homeostatic Range (NHR) that encompasses body temperature, pH, blood glucose level, blood cholesterol level, blood pressure, heart rate, respiratory rate, etc., Homeostasis tightly regulates NHR of all the physiologic parameters to develop homeostatic competence. Homeostatic competence is quite impossible without all the physiologic parameters harmoniously integrating with each other and working in their respective NHR. Physiologic parameters in NHR can be called as homeostatic factors. Deviation of even one physiologic parameter from its NHR could lead to temporary or permanent health disturbance due to disrupted homeostasis. But diseases tend to arise as a result of disturbance in all the physiologic parameters at the same time, though some or many of them could go unnoticed in the contemporary diagnostic procedures or due to lack of appropriate diagnosis. The homeostatic competence (or perfect homeostasis) of individuals that resists non-communicable diseases could also help resisting infectious diseases or vice versa. If only the data of physiologic parameters responsible for preventing non-communicable diseases are available, the health care professionals should be able to get a standpoint about the immunologic fitness of an individual (immunocompetent or immunocompromised) or if only the data of physiologic parameters responsible for immunologic fitness are available, the health care professionals should be able to get a standpoint about an individual’s ability to resist non-communicable diseases. These postulates on homeostatic competence can be made irrefutable by carefully reviewing the literature to establish associations between various homeostatic factors and the versatile roles played by each homeostatic factor in (i) preventing infectious diseases and non-communicable diseases (ii) maintaining pH and (iii) ensuring perfect homeostasis. Advancing Estimation and Gradation of Immunologic Status (AEGIS) can also be constructed putting together all homeostatic factors. Under the beneficial ecological conditions and lifestyle, human body as a biochemical machine would strive to adapt and converge all the versatile efforts of homeostatic factors to create perfect homeostasis for itself in association with a NHR for pH. Undoubtedly, at any age, Homeostatic Excellence Actuates Life Through Health (HEALTH) is naturally possible. KEY WORDS: Homeostasis, pH, Acid-base balance, Exercise, Nutrition, Ageing, Immunity, Infections, Non-communicable diseases, Public health

Impeccable Metabolic Maneuvers Upbring Natural Immunity To You [IMMUNITY]. Homeostatic competence of human body is an output of meticulous and interdependent/integrated/impeccable metabolic functions to resist or overcome diseases and facilitate a lengthy lifespan along the healthy ageing trajectory. Principles of homeostasis are seldom employed in the clinical applications. Perhaps this has led to almost an irreparable derailment of ethics and core competence of medical profession. Ivan Dominic Illich emphasized his criticisms on iatrogenesis and argued that modern medicine had hubristically taken on a mission to eradicate pain, sickness, even death but expropriated the autonomous power of humans to cope with their ailments. It is also quite obvious that the medical profession has failed to learn about ‘healthy individuals’ elaborately. Healthy individuals possess quintessential epigenetic efficiency and homeostatic competence built through several years of disciplined lifestyle, and especially their fitness characteristics are incomparably superior to individuals who never or rarely display propensity to improve their health standards. The disastrous perception of Immunology that ‘Best Homeostasis’ and ‘Worst Allostasis’ are same, hence all the individuals regardless of their health status are equally a potential source of disease transmission during an infectious disease outbreak, has caused severe disruption in various aspects of human life across the globe. Even the healthiest/fittest athletes and outstanding exercisers could asymptomatically transmit an infection to unhealthy people [who led an unhealthy lifestyle] whose disease could be anywhere in the allostasis spectrum ranging from early-stage co-morbidities to severe functional deterioration? Under the aegis of homeostasis and non-specific antibodies [Secretory IgA], a long-lasting Natural Immunity [NI] should be possible excluding the need of ‘specific antibodies’. Expanded Trained Immunity [ETI] proposed by Cassone has been found not only in innate immune system but also in nonimmune cells [both cells of hematopoietic and nonhematopoietic origin] associated with immunological memories from previous microbial encounters. Interesting discoveries about NI and ETI could emerge if they are linked with homeostasis and allostasis to develop objective immunologic tests to differentiate the healthy and unhealthy individuals, and enhance the clarity of immunology. Exercises are strongly linked to immunity; thus, measurements of exercise performance standards could accurately reveal the status of NI of the individuals if exercise performance data are systematically interpreted and correlated with immunologic function. Exercise performance data can be gathered using easily accessible non-invasive inexpensive tools. From the perspectives of homeostasis, we may not have distinct departments in the body to curb/defeat immunological or other non-immunological diseases, but any disease could be a threat to recovery to pre-existing conditions or even survival, if the homeostatic functions are impaired by iatrogenesis. KEYWORDS: Homeostasis, Innate Immunity, Adaptive Immunity, Exercise, Epigenetics, Trained Immunity, Secretory IgA, Allostasis, Immunosenescence, Iatrogenesis.

Health may not be a perfect balance point but efforts can be made to maintain the health in a perfect homeostatic range. Disrupted homeostasis is the underlying issue of all the diseases. Larger and longer the deviations of the body from homeostatic conditions, poorer the ability to regain the original functions will be. George E Billman stated ‘Homeostasis: The Underappreciated and Far Too Often Ignored Central Organizing Principle of Physiology'. Lack of clinical diagnosis and treatments on the basis of homeostasis could lead to public health damage, disingenuous medical curriculum, and eventually iatrogenic pseudoscience. Ivan Illich criticized iatrogenesis caused by treatments, health policies, medicalization of life and eradication of autonomous coping skills during illnesses. Antonovsky distinctly stated the salutogenesis was not limited by the disciplinary borders of one profession but rather an interdisciplinary approach and a question of bringing coherence between disciplines and realise what connects them through the people’s ability to comprehend the whole situation and the capacity to use the resources available [called as sense of coherence - SOC] to move in a health promoting direction. Prevention or healing of homeostatic disturbances obviously need interdisciplinary approach of various medical specializations including Physiotherapy. Intensifying impeccable prophylaxis, clinical applications and public health policies on the basis of homeostasis need in-depth and persistent emphasis on ‘Homeostaticology’, ‘Iatrogenicology’ and ‘Salutogenicology’. KEY WORDS: Homeostasis, Iatrogenesis, Public health, Kinanthropometry, Salutogenesis, Stress, Eustress, Epigenetics, Exercise, Spiritual intelligence, Yerkes-Dodson Law.