The synthesis of bradykinin analogues is described in which the Gly'-Phes, Phes-Ser6 or the Pro7-Phea peptide bond has been replaced by a trans carbon-carbon double bond or by a "reduced" peptide bond. Some of the analogues display high potency and prolonged activity in the rat blood pressure test, indicating increased metabolic stability. A clear selectivity is obtained towards the myotropic effect in the guinea pig i leum.Bradykinin (BK) Arg' -Pro2 -Pro3 -Gly' -Phes -Ser6 -Pro7 -Phe* -Argg A r g -P r o -P r o -G l y -P h e -S e r -P r o $

No abstract