Background: Nanotechnology brings a massive revolution in the domain of medical biotechnology. Plants possess thousands of antimicrobial compounds; these compounds can be extracted and utilized in the production of medicines. Objective: The aim of this research is to design an economic way for the formation of nanoparticles from plants and explore their antibacterial activity. Methods: In the present study, we used the plants, such as Aloe barbadensis, Azadirachta indica, Carica papaya, Mentha arvensis, and Catharanthus roseus. Ethanolic, methanolic, and aqueous extracts of the above-mentioned plants were used to prepare silver nanoparticles. Antimicrobial activities of the nanoparticles of extracts were determined against pathogenic strains of bacteria. Results: Results showed that silver nanoparticles are formed from the ethanolic and methanolic extracts of Azadirachta indica, Carica papaya, Mentha arvensis, and Catharanthus roseus and from the aqueous extracts of Aloe barbadensis and Mentha arvensis. It was observed that nanoparticles of ethanolic extracts of Azadirachta indica, Carica papaya, Mentha arvensis, and Catharanthus roseus exhibited the highest antibacterial activity against Pseudomonas species, E.coli, Pseudomonas specie, and S.typhi, respectively. On the other hand, the nanoparticles of methanolic extracts of Carica papaya, Mentha arvensis, and Catharanthus roseus showed the highest inhibition against E.coli, whereas, maximum zone of inhibition of Pseudomonas was observed by the action of methanolic extract of Azadirachta indica. It is also found that nanoparticles of the aqueous extracts of Aloe barbadensis and Mentha arvensis inhibited the pathogenic strains and showed maximum activity against Pseudomonas and E.coli, respectively. Conclusion: The above results indicate that the nanoparticles formed from the extracts of the tested plants have high antimicrobial potential and could be utilized in the preparation of medicines to treat various disorders.

Background: At the present time skin problems need to address seriously, antibiotic resistance development is very fast in skin infectious bacteria. For the prevention of all types of skin infections, natural plant extracts can provide suitable defense line because they contain active compounds. Wrinkles, sunburn, itching, black heads, white heads and uneven tone of the skin are the collective issues related to skin. Extensive use of antibiotics for skin diseases is restricted due to the development of worse antibiotic resistance. Objective: In this study the antibacterial potential of plant extracts was assessed against skin infectious bacteria to get alternative cure of skin diseases. Method: Staphylococcus aureus, Staphylococcus epidermidis strains were isolated from clinical samples and E.coli was used as non-pathogenic control strain from Jinnah University for Women strain repository. Their antibacterial activity was performed against eight plant extracts through well diffusion method. Result: Among eight plant extracts, Neem (Azadirachta indica), Turmeric (Curcuma longa), Sandalwood (Santalum album), Shahtara (Fumaria parviflora) Chirayata (Swertia chirayita) and commercially available mixed Citrus peel showed good inhibition of bacterial growth. Discussion: Natural sources such as fruits, herbs, minerals, leaves, flowers, roots, honey and rose water are now becoming part of skin care and treatment products because they possess antimicrobial activities. Skin products with herbal ingredients are now evolving as suitable solutions to the existing skin problems.