crucial part in many human activities due to their unique size-dependent properties, i.e., the size of the particle will predict its properties and NPs of the same kind but of different sizes vary from each other 2) . Physiochemical properties of NPs such as ultra-small size, large surface area to mass ratio, and high reactivity 3) are different from those of their bulk form 4) .

IntroductionBiological systems have evolved as a revolutionary technology for synthesizing nanoparticles (NPs) in recent years. Synthesis of NPs expanded greatly in the past few decades by manipulating their properties which makes the research area to grow bigger 1) . With 1-100 nm NPs size, they are utilized in medical industries, catalysis, electro-chemistry biosensors, water treatment, and trace substance detection 2) . They are synthesized by using chemical, physical and biological methods. Depending upon the external environment, NPs may be hollow, spherical, cylindrical, flat and