Sheep and goat undergoes various stresses throughout their life cycle, among various causes of these stresses pregnancy and diseases are the most common one which widely affected these two ruminants. The aim of this study was to investigate the effect of pregnancy and disease stress on antioxidative capacity of the sheep and goat, which in turn screens the total health status of the animal under study. Forty goat and sheep females (20 each) in two groups viz 15 diseased & pregnant and 5 healthy females without pregnancy and diseases (control) were investigated for variations in the antioxidative capacity. Result of study revealed that acw value (the water soluble antioxidative capacity) was reported lowest in pregnant sheep (5.75mg/l), whereas this value was reported highest in the control group (7.08 mg/l) which concluded that stress caused by pregnancy or disease reduced the antioxidative capacity of goat and sheep as compared the control group. Similar trends were reported in the goat also.