Leptospirosis is an important re-emerging infectious disease. Leptospirosis has been estimated to affect tens of millions of humans annually with a case fatality rate ranging from 5% to 25%; however, it is underreported due to the lack of clinical suspicion and barriers to diagnostic capacity. A 33-year-old healthy male presented with a history of fever of 2-day duration. His examination revealed icterus. His workup did not show any significant findings except for a mild transaminitis and a rise in serum creatinine by 0.5 mg/dl. Later, the patient developed bradycardia. An ELISA test for Leptospira antibodies was positive. The patient recovered after a course of intravenous antibiotics. Leptospirosis should be considered early in the diagnosis of any patient who presents with acute, nonspecific febrile illness with multiorgan involvement. Our case had an atypical presentation with involvement of the cardiovascular system in the form of junctional rhythm.

There was a trend towards a higher proportion of medium to large RLS (>10 microembolic signals) in OSA subjects compared to controls (63.2% versus 30%, p = 0.13). Conclusion: An increased prevalence of RLS occurs in OSA subjects. This may lead to worse desaturation and symptoms of OSA. Further studies could address the pathophysiological and treatment implications of this potentially significant association.

No abstract

No abstract

No abstract