The alphaherpesvirus UL51 protein is a tegument component that interacts with the viral glycoprotein E and functions at multiple steps in virus assembly and spread in epithelial cells. We show here that pUL51 forms a complex in infected cells with another conserved tegument protein, pUL7. This complex can form in the absence of other viral proteins and is largely responsible for recruitment of pUL7 to cytoplasmic membranes and into the virion tegument. Incomplete colocalization of pUL51 and pUL7 in infected cells, however, suggests that a significant fraction of the population of each protein is not complexed with the other and that they may accomplish independent functions. IMPORTANCEThe ability of herpesviruses to spread from cell to cell in the face of an immune response is critical for disease and shedding following reactivation from latency. Cell-to-cell spread is a conserved ability of herpesviruses, and the identification of conserved viral genes that mediate this process will aid in the design of attenuated vaccines and of novel therapeutics. The conserved UL51 gene of herpes simplex virus 1 plays important roles in cell-to-cell spread and in virus assembly in the cytoplasm, both of which likely depend on specific interactions with other viral and cellular proteins. Here we identify one of those interactions with the product of another conserved herpesvirus gene, UL7, and show that formation of this complex mediates recruitment of UL7 to membranes and to the virion. Human herpesviruses can reactivate from latency at internal anatomical sites and be shed from epithelial surfaces long after initial infection and establishment of an adaptive immune response (1-8). This suggests that the ability to spread from cell to cell in the presence of immune effectors is a conserved property of herpesviruses. Within the alphaherpesviruses, where this phenomenon has been the most extensively studied, the evidence suggests that cell-to-cell spread (CCS) between epithelial cells in vitro has two mechanistic components. The first of these is a virion trafficking component in which virions are targeted from the site of secondary envelopment to the junctional surfaces of cells, where they have access to adjacent cells in a compartment that is sterically protected from immune effectors in the medium (9-11). The second component is a specialized entry process that may involve gE binding to specific CCS receptors and that also may involve different patterns of receptor usage by the virus entry apparatus (12-15). In alphaherpesviruses, both mechanistic components involve the complex between the envelope glycoproteins gE and gI. However, since gE and gI are encoded only by alphaherpesvirus genomes, any mechanism for CCS that is conserved among all herpesviruses is likely to involve other, more widely conserved viral factors.Virus genome-encoded proteins that are specifically required for epithelial CCS fall into two categories: those required for virus entry into cells regardless of the mode of virus egress and those tha...

One of the most relevant yet misunderstood questions within talent management is how to successfully identify high-potential employees-people who will, when called upon, step up and actually deliver in larger roles with more responsibility. Almost every organization is faced with this dilemma, and often, the only source of information to predict future success is past job performance. But this information is not enough to go on; in fact, it is terribly incomplete. We know that to succeed at the next level, particularly if this is not a simple expansion of one's existing role, it may take something quite different. And, of course, the cost of getting it wrong can be devastating in today's environment of fast change and economic recession.Silzer and Church (2009) have thoroughly summarized the current state of the literature and practice on potential. There are, however, still quite a few unanswered questions. We hope to address one key point that was briefly addressed in the focal article: confusing performance with potential and, in turn, how to effectively guide a discussion of talent that considers both.

The present study examined the relationships between personality, coping strategies, and health ratings to extend past research to people living with chronic hepatitis C (HCV). Participants were 35 people (11 men, 24 women; M age = 49.6 yr., SD = 10.6) living with chronic hepatitis C for an average of 9.0 yr. (SD = 6.0) since diagnosis. Participants provided descriptions of stressful situations and responded to a personality inventory, Ways of Coping Questionnaire scales (planful problem solving and escape-avoidance) and SF36 Health Survey scales measuring physical functioning and mental health. The stressful situations were judgmentally clustered into seven dimensions (diagnosis/mortality, disclosure, stigma, social and work role functioning, compounding problems, and no stress). Correlational analyses indicated strong negative relationships between escape-avoidance coping and health measures. Emotional Stability and Extraversion were positively related to both health variables, and Extraversion was negatively related to escape-avoidance coping. The results suggest that research from other contexts that has examined these relationships tended to generalize to people living with HCV.