Humans naturally have an orientation toward forging social connections, and they suffer both physically and psychologically when denied those connections. Individuals can be denied a sense of social connection in various ways, sometimes via direct negative attention (e.g., rejection) or other times by complete inattention (e.g., ostracism). These diverse experiences can be considered types of social exclusion, broadly defined as being kept apart from others physically or emotionally. In this article, we provide a brief overview of the empirical literature on social exclusion. Then we highlight new areas of research that provide future opportunities to help the literature continue to mature and interface with other research areas, both within psychology and beyond.