Background
Little is known about mucocutaneous disease in acutely-ill children and adolescents with COVID-19 and MIS-C.
Objective
To characterize mucocutaneous disease and its relation to clinical course among hospitalized patients with COVID-19 and MIS-C.
Methods
Descriptive cohort study of prospectively and consecutively hospitalized eligible patients between May 11, 2020 and June 5, 2020.
Results
In COVID-19 patients, 4/12 (33%) had rash and/or mucositis, including erythema, morbilliform pattern, and lip mucositis. In MIS-C patients, 9/19 (47%) had rash and/or mucositis, including erythema, morbilliform, retiform purpura, targetoid and urticarial patterns, along with acral edema, lip mucositis, tongue papillitis, and conjunctivitis.
COVID-19 patients with rash had less frequent respiratory symptoms, PICU admission, and invasive ventilation, as well as shorter stay (vs COVID-19 without rash). MIS-C patients with rash had less frequent PICU admission, shock, ventilation, as well as lower levels of CRP, ferritin, D-dimer, and troponin (vs MIS-C without rash). Neutrophil-to-lymphocyte ratio was similar for patients with and without rash in both groups. None of the MIS-C patients met criteria for Kawasaki disease.
Limitations
Small sample sizes.
Conclusions
Mucocutaneous disease is common among children and adolescents with COVID-19 and MIS-C. Laboratory trends observed in patients with rash may prognosticate a less severe course.
Background: Limited information exists on mucocutaneous disease and its relation to course of COVID-19.Objective: To estimate prevalence of mucocutaneous findings, characterize morphologic patterns, and describe relationship to course in hospitalized adults with COVID-19.
The chronic inflammatory state in hidradenitis suppurativa (HS) may result in development of clonal immune cell populations which give rise to malignant lymphomas. Our objective was to investigate prevalence of non-Hodgkin lymphoma (NHL), Hodgkin lymphoma (HL), and cutaneous T-cell lymphoma (CTCL) among patients with HS.
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