Bipolar disorder is a chronic and recurrent disorder, a brain disorder that causes changes in a person’s mood, energy, and ability to function. Patients have alternate increased mood and activities (mania, hypomania, or “ups” period) and declining mood and activities (depressive or “downs” period) in their life. Symptoms of the manic episodes of bipolar disorder include sensitive feelings, lack of rest, and shot up self-esteem, while the depressive episodes bring loss of interest, more or less sleep than usual, anxiety, a feeling of worthlessness, and lack of concentration. Bipolar disorder is a severe mental disorder with a fairly high prevalence of 1%- 2% and is the 5th cause of disability in the world. Many factors have been considered to contribute to this disorder. While there is strong evidence that some genetic and environmental factors are associated with bipolar disorder, only a few can provide sufficient evidence to establish causality. This report discusses the case of a new manic episode of bipolar disorder that occurs in a woman aged 25 years old who works as a public figure, announcer, and entertainer. The patient has been hospitalized several times and received various pharmacotherapy and psychotherapy but still having difficulties in managing the ups and downs of her emotion. A lot of individual factors must be considered in managing patients with bipolar disorder.