Pseudomonas aeruginosa is one of the major bacteria for nosocomial infections because the conditions are favourable for its growth and with multidrug resistance to various antibiotics. Homoeopathy, the system of medicines which doesn't show any adverse reaction is considered safe for administration. The homoeopathic medicines Barosma Crenata 30CH, Holarrhena Antidysenterica 30CH, Laurocerasus 6CH gave more than 75% inhibition in single-dose, whereas gave inhibition of more than 84% when administered in repetition. These medicines were also given in conjunction with different medicines in double and triple doses where inhibition was more than 83% and 87% respectively. Out of all the medicines selected for the experiments, Laurocerasus 6CH gave the most inhibition i.e. 90.91%, which gave more inhibition then Doripenem per cent inhibition (86%).